E4-6/7 protein forms a complex with two E2F transcription factors and induces the cooperative and stable binding of this complex to the palindromic E2F-binding site structure present in theE2promoter20and in theE1Apromoter of ICOVIR-15, activating a positive feedback that should culminate in higher production of virus progeny and lysis of the tumor cell
E4-6/7 protein forms a complex with two E2F transcription factors and induces the cooperative and stable binding of this complex to the palindromic E2F-binding site structure present in theE2promoter20and in…